Effect of stimulation of Parasympathetic and sympathetic

Autonomic Receptors

Parasympathetic

(Cholinergic Receptors)

1-Peripheral Cholinergic

Muscarinic Acetylcholine Receptors

(Muscarinic Receptors)

2-Central Cholinergic

Nicotinic Acetylcholine Receptors

(Nicotinic Receptors)

Stimulated by low conc. Of nicotine

Blocked by high conc. Of nicotine

NM

(Nicotinic Muscle)

-Neuromusclar junction

(NMJ) in skeletal muscle.

NN

(Nicotinic Neural)

-Autonomic ganglia

-Adrenal medulla

-CNS

Opening Na+ & K+ channels.

(Ligand-gated ion channels)

Stimulated by muscarine

Effect of stimulation of

Parasympathetic and sympathetic

 

Organ	Parasympathetic stimulation		Sympathetic stimulation
EYE	-  Contraction circular muscle à Miosis   -  Contraction ciliary muscle  à accommodation for near vision.	M3	-Contraction radial muscle Mydriasis	α1
			-Relaxation ciliary muscle àaccommodation for far vision.	β2
Heart	Decrease cardiac properties:  -  (-ve) Inotropic.  -  (-ve) Chronotropic.  -  (-ve) Dromotropic.	M2	Increase cardiac properties:  -  (+ve) Inotropic.  -  (+ve) Chronotropic.  -  (+ve) Dromotropic.	β1
Bronchi	- Bronchoconstriction -increase Bronchial secretion.	M3	Bronchodilatation.	β2
GIT	-  Contraction of wall and increase Motility.    -  Relaxation of sphincters.	M3	Relaxation of wall and decrease Motility.	β2
			Contraction of sphincters.	α1
Urinary Bladder	-  Contraction of wall . -  Relaxation of sphincters.	M3	Relaxation of wall	β2
			Contraction of sphincters	α1
Uterus	-     Contraction.	M3	Relaxation	β2
			Contraction.	α1
Salivation	-incease salivation ( watery)	M1	-Viscous secreation	β1
Blood Vessels	Vasodilatation(VD) via release of NO	M3	Vasoconstriction(VC)	α1
			Vasodilatation on skeletal muscle.	β2
Sex Organ	-Erection (Vasodilatation via increase NO)	M3	-Ejaculation	α1
Insulin	-----------------------------------------------------	----	Decrease insulin release.	α2

 

 

-   Inotropic à Force of contraction. 

-   Chronotropic à Heart rate. 

-   Dromotropic à Conduction of the electrical impulses    in the heart. 

-   Bradycardia à Heart slowness.

Tachycardia Accelerated of the heart. 

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